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Code: a10251
Journal: Acta Paediatrica (December 2007)
Authors: Eisenmann JC
Purpose: This review evaluated the concepts of and associations between fitness, fatness, and the [metabolic syndrome (MetS)] in children and adolescents.
Results: The author states that the correlation between fatness and MetS remains significant after controlling for fitness, whereas the correlation between fitness and MetS does not remain significant after controlling for fatness, a phenomenon that may involve genetics, adipocytokines and mitochondrial function. The author suggests that further studies need to be conducted to understand the role of physical activity and other environmental factors on this phenomenon.
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Code: a10252
Journal: Circulation (February 2008)
Authors: Tang W, Yang Y, Wang B, Xiao C
Purpose: To investigate the association between this polymorphism and essential hypertension (EH) in Hani (n = 305 individuals) and Yi (n = 233 individuals) minorities of China.
Results: Researchers reported that there was a significant difference in G894T genotype distribution between NTs and hypertensives in both Hani and Yi populations.
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Code: a10254
Journal: American Journal of Nephrology (January 2008)
Authors: Biswas SK, Peixoto EB, Souza DS, Lopes de Faria JB
Purpose: To evaluate the pro-oxidant and antioxidant mechanisms responsible for the induction of renal oxidative stress in the presence of hypertension and diabetes mellitus.
Results: Researchers concluded that hypertension increases pro-oxidant generation and decreases antioxidant defense, and thereby induces renal oxidative stress in early diabetes.
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Code: a10255
Journal: Behavioural Brain Research (February 2008)
Authors: Fox AT, Hand DJ, Reilly MP
Purpose: To test the theory that, because ADHD in humans is partially defined by marked impulsivity, spontaneously hypertensive rats (SHR), if a valid model of ADHD, ought to behave more impulsively than their normotensive parent strain, Wistar Kyoto (WKY).
Results: Researchers reported that SHRs were shown to be more impulsive than the WKYs as defined by preference for smaller, immediate reinforcers over larger, delayed ones in an intertemporal choice procedure.
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Code: a10256
Journal: International Journal of Cardiology (January 2008)
Authors: Svensson S, Linell P, Kjellgren K
Purpose: To determine whether patients and physicians put measured values of target blood pressure levels into context when assessing whether they are well controlled or too high.
Results: Analysis of study data suggests that patients and physicians make sense of the blood pressure through a contextualization process which tends to normalize the face values towards the reference values, and that the resulting (processed) value is the one acted upon.
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Code: a10253
Journal: Cardiovascular Drug Reviews (Winter 2007)
Authors: Jakubowski JA, Winters KJ, Naganuma H, Wallentin L
Purpose: To provide a mechanistic basis for the faster, greater, and more consistent inhibition of platelet aggregation observed with prasugrel.
Results: Clinical studies in patients with cardiovascular disease confirmed the potent antiplatelet effect of prasugrel compared with clopidogrel, and researchers noted that these phase 1/1b studies and a phase 2 study (JUMBO-TIMI 26) aided in dose selection for the recently completed phase 3 trial (TRITON-TIMI 38) in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
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